Relationship between autophagy and T2DM and intervention effect of traditional Chinese medicine.
- Author:
Jin-ni HONG
;
Wei-wei LI
;
Xue-mei WANG
- Publication Type:Journal Article
- MeSH:
Animals;
Autophagy;
drug effects;
Diabetes Mellitus, Type 2;
drug therapy;
metabolism;
physiopathology;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Insulin;
metabolism;
Insulin Resistance;
Insulin-Secreting Cells;
cytology;
drug effects;
metabolism
- From:
China Journal of Chinese Materia Medica
2015;40(22):4351-4354
- CountryChina
- Language:Chinese
-
Abstract:
Insulin resistance and insulin secretion deficiency are main machanisms in inducing type 2 diabetes mellitus (T2DM), and mitochondria damage plays an important role in them. Research shows that autophagy is a self-protective mechanism of cells, which plays an important role in maintaining the normal structure and function of pancreatic β cells and improving insulin resistance. Previous studies show that traditional Chinese medicine can regulate cell autophagy to influence β cells and insulin resistance, type 2 diabetes mellitus and its complications. Thus this review will talk about the process of the relationship between autophagy and T2DM and the intervention effect of traditional Chinese medicine.
