Interleukin-18 and its related cytokines in plasma of patients with idiopathic thrombocytopenic purpura.
- Author:
Lu-Qin ZHANG
1
;
Jin-Yuan GE
;
Yu-Lin GUO
;
Hui-Ren ZHAO
Author Information
1. Department of Hematology, The First People's Hospital of Xuzhou, Xuzhou 221002, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Child;
Child, Preschool;
Complement Membrane Attack Complex;
analysis;
Female;
Humans;
Interleukin-18;
blood;
Male;
Middle Aged;
Purpura, Thrombocytopenic, Idiopathic;
immunology;
Tumor Necrosis Factor-alpha;
analysis
- From:
Journal of Experimental Hematology
2003;11(6):662-664
- CountryChina
- Language:Chinese
-
Abstract:
To explore the role of immune regulating cytokines in pathogenesis of the idiopathic thrombocytopenic purpura (ITP) and its clinical significance, the levels of IL-18, TNF-alpha and Sc5b-9 in plasma of 32 ITP patients and 18 normal individuals were detected using ELISA methods. The results showed that IL-18, TNF-alpha and sC5b-9 levels in plasma of ITP patients were higher than that in normal individuals. The level of IL-18 was positively correlated with the levels of TNF-alpha and sC5b-9. In conclusion, The rising levels of the IL-18, TNF-alpha and sC5b-9 were correlated with disorder of Th1/Th2 subsets, and may contribute to the immune dysfunction in ITP patients. The dynamic observation of these cytokines may be useful in directing the clinical treatment for ITP patients.
