Differential Expression Profiles of MicroRNAs between de novo and Complete Response Severe Aplastic Anemia.

Ying-Qi SHAO; Hong-Yu DONG; Mei-Li GE; Feng ZHANG; Jun SHI; Xing-Xin LI; Jin-Bo HUANG; Zhen-Dong HUANG; Jing ZHANG; Neng NIE; Yi-Zhou ZHENG

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Differential Expression Profiles of MicroRNAs between de novo and Complete Response Severe Aplastic Anemia.

VernacularTitle:新发和完全缓解的重型再生障碍性贫血间microRNA差异表达谱
Author: Ying-Qi SHAO ¹ ; Hong-Yu DONG ² ; Mei-Li GE ¹ ; Feng ZHANG ³ ; Jun SHI ¹ ; Xing-Xin LI ¹ ; Jin-Bo HUANG ¹ ; Zhen-Dong HUANG ¹ ; Jing ZHANG ¹ ; Neng NIE ¹ ; Yi-Zhou ZHENG ⁴
Author Information

1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
2. Shijingshan Teaching Hospital of Capital Medical University, Beijing Shijingshan Hospital, Beijing 100043, China.
3. Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
4. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.E-mail: zheng_yizhou@hotmail.com.
Publication Type:Journal Article
From: Journal of Experimental Hematology 2018;26(1):213-218
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo detect the expression of miRNA in de novo and complete response SAA patients and predict the targets of the miRNAs.
METHODSThe expression profiles of miRNA from bone marrow mononuclear cells of the SAA patients with de novo and CR were detected by miRNA microarray.
RESULTSTotally 35 up-regulated and 37 down-regulated miRNA were identified in CR SAA patients in comparison with de novo SAA patients. Furthermore, by predicting the targets of the differentlly expressed miRNA, it was found that some targets associated with T cell receptor signaling pathway and cell adhesion molecules.
CONCLUSIONSome miRNA may be involved in the pathogenesis of SAA.