Clinical analysis of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation.
- Author:
Zhi GUO
1
;
Hui-Ren CHEN
;
Xiao-Dong LIU
;
Jia-Ming BIAN
;
Xue-Peng HE
;
Jin-Xing LOU
;
Peng CHEN
;
Kai YANG
;
Dan LIU
;
Yuan ZHANG
Author Information
1. Department of Hematology, Beijing Military Area General Hospital, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Child;
Child, Preschool;
Cytomegalovirus Infections;
drug therapy;
etiology;
Female;
Foscarnet;
therapeutic use;
Ganciclovir;
therapeutic use;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
adverse effects;
Humans;
Male;
Middle Aged;
Retrospective Studies;
Risk Factors;
Transplantation, Homologous;
Young Adult
- From:
Journal of Experimental Hematology
2012;20(4):971-974
- CountryChina
- Language:Chinese
-
Abstract:
The objective of this study was to explore the incidence and therapeutic efficacy of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 140 patients undergoing allo-HSCT in our department of hematology from 2010-01 to 2012-01 were retrospectively analyzed. The results showed that the incidence of CMV infection was 4.3% (48/140), the time for the first detection of positive CMV-DNA was at day 45 (33 to 68) after allo-HSCT, and the CMV quantitative range was 1.25×10(3) - 5.5×10(6). There were 2 cases of CMV-related interstitial pneumonia and 5 cases of hemorrhagic bladder inflammation. A total of 65 patients suffered from graft versus host disease (GVHD), in which 32 cases (49.2%) were accompanied with CMV infection, CMV-DNA negative in patients treated with ganciclovir, foscarnet sodium anti-CMV was at day 45 (33 to 68) with the effective rate of 100%. 12 patients with CMV infection were accompanied with transient neutropenia and thrombocytopenia. It is concluded that after allo-HSCT the CMV infection occurs frequently. The patients with GVHD have a higher incidence of CMV infection. Ganciclovir and foscarnet sodium are reliable to be used for treatment of CMV infection with fewer adverse reactions.
