A new furan-2-carboxylic acid from stem bark of Cassia alata.

Author: Ling ZHOU ¹ ; Wei DONG ¹ ; Yue-de WANG ² ; Kun ZHOU ² ; Hang-Ying MA ² ; Yan YANG ² ; Huan-Huan XING ² ; Min ZHOU ² ; Qiu-Fen HU ² ; Yan-Qing YE ¹
Author Information

1. College of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, China.
2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, China.
Publication Type:Journal Article
Keywords: Cassia alata; Dai medicine; cytotoxic activity; furan-2-carboxylic acids
From: China Journal of Chinese Materia Medica 2016;41(14):2652-2654
CountryChina
Language:Chinese
Abstract: A new furan-2-carboxylic acid, 5-[3-(hydroxymethyl)-4,5-dimethoxyphenyl]-3-methylfuran-2-carboxylic acid(1),has been isolated from the bark of Cassia alata by using various chromatographic techniques. It displayed cytotoxicity against NB4, A549, SHSY5Y, PC3 and MCF7 cell lines with IC₅₀ values of 2.5, 1.2, 2.2, 3.6 and 1.9 μmol•L⁻¹, respectively.