Construction and application of natural products LC-MS-DS.
- Author:
Jia-Yu ZHANG
1
;
Peng-Fei TU
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center Beijing 100191, China.
- Publication Type:Journal Article
- MeSH:
Biological Products;
analysis;
Chromatography, High Pressure Liquid;
methods;
Databases, Factual;
Flavanones;
analysis;
Murraya;
chemistry;
Search Engine;
methods;
Spectrometry, Mass, Electrospray Ionization;
methods;
Tandem Mass Spectrometry;
methods
- From:
Acta Pharmaceutica Sinica
2012;47(9):1187-1192
- CountryChina
- Language:Chinese
-
Abstract:
To overcome the defects of current research methods of natural products, an LC-MS-DS that consisted of more than 600 natural products was constructed with HPLC-ESI-IT-MS/MS. The database searching results of LC-MS-DS were validated to be reliable, which indicated that LC-MS-DS could be successfully applied for the effective identification and target isolation of natural products. The study will provide an effective method for fast identification and efficient isolation of natural products.
