Comparison of 4 types of coronary heart disease model of Qi-deficiency and blood-stasis syndrome in rats.

Shuo HUANG; Jian-Xun LIU; Lei LI; Bin YANG; Qing XU; Qiong WANG

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Comparison of 4 types of coronary heart disease model of Qi-deficiency and blood-stasis syndrome in rats.

Author: Shuo HUANG ¹ ; Jian-Xun LIU ¹ ; Lei LI ¹ ; Bin YANG ¹ ; Qing XU ² ; Qiong WANG ³
Author Information

1. Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Beijing 100091, China.
2. Core Facilities for Electrophysiology, Core Facilities Center, Capital Medical University, Beijing 100069, China.
3. Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China.
Publication Type:Journal Article
Keywords: Qi-deficiency and blood-stasis; animal model; coronary heart disease; disease-syndrome combination
From: China Journal of Chinese Materia Medica 2016;41(22):4216-4225
CountryChina
Language:Chinese
Abstract: This paper was aimed to establish a method for coronary heart disease in rats with Qi-deficiency and blood stasis of the stable by comparing different model establishment methods (L group: ligation of coronary artery, EL group: exercise fatigue combine ligation of coronary artery, DL group: diet combine ligation of coronary artery, DEL group: diet, exercise fatigue combine ligation of coronary artery). After 6 weeks postoperatively, both the method of L (ligation of coronary artery) and DL, EL, DEL (multi-originated information complex) could be successfully established by coronary heart disease model of Qi-deficiency and blood-stasis syndrome type in rats. Model set up by using the compound factors (DL, EL, DEL), and through simple ligation of coronary artery to build model (L) to compare the clinical etiology and linked, DL, EL and DEL were more closely with relevant theoretical system of traditional Chinese medicine (TCM) and have a certain advantage in complete reflect the characteristics of TCM syndrome. Among three kinds of compound factors model, EL model compared with other two models DL and DEL was more consistent with clinical practical reasons and characteristics of the disease. Through EL the CHD deficiency of blood stasis rat model of combined disease could be controlled and good repeated.