Monitoring indexes for early renal injury in the workers exposed to mercury.
- Author:
Shan-zhuo PENG
1
;
Chun-sheng ZHANG
;
Yuan HU
;
Jie ZHANG
;
Mingzhi WEI
;
Lu LIU
;
Ying WANG
Author Information
- Publication Type:Journal Article
- MeSH: Acetylglucosaminidase; urine; Adult; Albuminuria; urine; Creatinine; urine; Female; Humans; Kidney; injuries; physiopathology; Kidney Diseases; etiology; urine; Male; Mercury Poisoning; complications; Middle Aged; Occupational Exposure; adverse effects; Retinol-Binding Proteins; urine; gamma-Glutamyltransferase; urine
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the diagnostic method for early renal injury in the workers exposed to mercury (Hg).
METHODSThe contents of urinary Hg were determined by chemical method. Urinary microalbumin (mALB), beta(2)-microglodulin (beta(2)-MG) and retinol binding protein (RBP) levels were measured with total quantitative enzyme immunoassay. The activities of urinary N-acetyl-beta-D-glucosaminidase (NAG) and gamma-glutamyl transferase (gamma-GT) were determined by rate methods. Urinary creatinine (Cr) was measured by using picric acid method.
RESULTSThe levels of urinary BRP, beta(2)-MG, NAG and gamma-GT in exposed workers [(439.7 +/- 201.4), (141.4 +/- 56.3) micro g/g Cr and (12.3 +/- 5.7), (60.3 +/- 18.5) U/g Cr respectively] were significantly higher than those in controls (P < 0.05, P < 0.01). The levels were increased gradually with the increasing contents of urinary Hg. The positive detection rate for single or two combined indexes was rather lower whereas that for 4 combined indexes was as high as 85.5%. A positive correlation was noted between the contents of urinary Hg and urinary BRP, beta(2)-MG, NAG and gamma-GT (r: 0.466, 0.379, 0.323, 0.311, P < 0.05). Urinary RBP was correlated to urinary beta(2)-MG, NAG and gamma-GT (r: 0.362, 0.354, 0.332, P < 0.05).
CONCLUSIONCombined detection of urinary RBP, beta(2)-MG, NAG and gamma-GT is a sensitive method for the diagnosis of early renal injury in the workers exposed to Hg.
