Design, synthesis and insulin-sensitizing activity of indole derivatives.
- Author:
Lei TANG
1
;
Yu-she YANG
;
Ru-yun JI
Author Information
- Publication Type:Journal Article
- MeSH: 3T3-L1 Cells; metabolism; Adipocytes; drug effects; Animals; Drug Design; Hypoglycemic Agents; chemical synthesis; pharmacology; Indoles; chemical synthesis; pharmacology; Insulin; pharmacology; Mice; Triglycerides; metabolism
- From: Acta Pharmaceutica Sinica 2006;41(3):225-229
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo design and synthesize compounds with insulin-sensitizing activity.
METHODSUsing association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells.
RESULTSOne of the synthesized compounds showed strong insulin-sensitizing activity in vitro.
CONCLUSIONThis compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.
