Correlations between preS1-antigen, HBV-DNA and HBV serum markers in patients with chronic hepatitis B.
- Author:
Hui ZHOU
1
,
2
;
Chu-wen JIANG
;
Jing-lin QIAN
;
Shi-jian LI
;
Jie-ling LIANG
;
Xue-fu CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Child; DNA, Viral; blood; Female; Hepatitis B Surface Antigens; blood; Hepatitis B e Antigens; blood; Hepatitis B virus; genetics; immunology; isolation & purification; Hepatitis B, Chronic; blood; immunology; virology; Humans; Male; Middle Aged; Protein Precursors; blood; Virus Replication; genetics; Young Adult
- From: Journal of Southern Medical University 2008;28(7):1184-1186
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the correlations between preS1 antigen, HBV-DNA and hepatitis B virus (HBV) serum markers in patients with chronic hepatitis B.
METHODSThe HBV markers, preS1 antigen and HBV-DNA were determined using enzyme- linked immunosorbent assay and quantitative PCR in 1158 patients with chronic hepatitis B.
RESULTSIn these patients, the HBV-DNA positivity rate was 68.9%, significantly higher than preS1 antigen positivity (54.8%, chi2=53.24, P<0.005). The positivity rates of both HBV-DNA and PreS1-antigen were significantly higher in HBeAg-positive patients than in HBeAg-negative patients (P<0.005). The coincident rates of preS1-antigen and HBeAg with HBV-DNA were 56.9% and 63.3%, respectively. PreS1 antigen had higher sensitivity but lower specificity than HBeAg. The detection rates of preS1 antigen and HBeAg increased with the level of HBV-DNA, and preS1 antigen positivity was higher than that of HBeAg in patients with low HBV-DNA levels.
CONCLUSIONDetection of HBV serum markers along with preS1 antigen and HBV-DNA may help assess the status of viral replication and therapeutic efficacy in patients with chronic hepatitis B. PreS1 antigen may serve as an auxiliary indicator in HBeAg-negative cases or when HBV-DNA detection is impossible.
