Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection.
- Author:
Jeong Woo HONG
1
;
Hyun Seon YOU
;
Tae Won LEE
;
Won Yong JO
;
Bo Ra KIM
;
Young Sun SUH
;
In Gyu BAE
;
Oh Hyun CHO
Author Information
- Publication Type:Case Report
- Keywords: Epstein-Barr virus infections; Lymphohistiocytosis, Hemophagocytic; Scrub typhus
- MeSH: Aged; Anti-Bacterial Agents; Bone Marrow; Bone Marrow Examination; Diagnosis; Doxycycline; Epstein-Barr Virus Infections; Fever; Herpesvirus 4, Human*; Histiocytes; Humans; Lymphohistiocytosis, Hemophagocytic*; Male; Polymerase Chain Reaction; Scrub Typhus*; Steroids
- From:Infection and Chemotherapy 2016;48(4):330-333
- CountryRepublic of Korea
- Language:English
- Abstract: There have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (HPS), most of which were treated successfully using adequate antibiotics. Here, we report a case of Epstein-Barr virus (EBV)-associated HPS after scrub typhus infection that was not improved using antirickettsial treatment. A 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-day doxycycline therapy. Physical and laboratory data showed hepatosplenomegaly, bicytopenia, hyperferritinemia, and hypofibrinogenemia. A bone marrow examination (BM) revealed hypercellular marrow with hemophagocytosis and histiocyte infiltration. EBV was detected in BM aspirates using polymerase chain reaction. After a diagnosis of HPS was made, the patient was treated successfully using high-dose steroids.
