Relationship between Mutation of IR in the mtr System of Neisseria Gonorrhoeae and Multiple Antibiotic Resistance
- Author:
Lixia ZHANG
1
;
Nengxing LIN
;
Changzheng HUANG
;
Hongxiang CHEN
;
Yun LIN
;
Yating TU
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
Neisseria gonorrhoeae;
gene mutation;
inverted repeat sequence;
antimicrobial sensitivity tests
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2006;26(2):248-250
- CountryChina
- Language:Chinese
-
Abstract:
To study the relationship between mutation of the inverted repeat sequence (IR) in the multiple transferable resistant system (mtr) of Neisseria gonorrhoeae (NG) and itsmultiple antibiotic resistance, minimal inhibitory concentrations (MICs) for the clinically isolated strains were tested by agar-dilution-method. The mtr system's IR gene of NG was sequenced after amplification by polymerase chain reaction (PCR). Either two susce ptive or five penicillin-resistant strains had no base mutation in IR gene, while all of the 13 strains with multiple-antibiotic-resistance had a singlebase deletion (A/T). The result suggests that a single-base deletion of the thirteen-base IR sequence in mtr system of NG might result in multiple antibiotic resistance but is not associated with single antibiotic resistance.
