Protective Effect of 10-Hz, 1-mT Electromagnetic Field Exposure Against Hypoxia/Reoxygenation Injury in HK-2 Cells.

Author: Soonho LIM ¹ ; Soo-Chan KIM ² ; Jae Young KIM ¹
Author Information

1. Department of Biological Science, Gachon University, Incheon, 406-799, Korea.
2. Department of Electrical and Electronic Engineering, Hankyong National University, Anseong-si, Kyonggi-do 456-749, Korea.
Publication Type:Letter
MeSH: Cell Hypoxia; Cell Line; Electromagnetic Fields; Humans; Kidney Tubules, Proximal; cytology; metabolism; radiation effects; Reactive Oxygen Species; metabolism; Reperfusion Injury; prevention & control
From: Biomedical and Environmental Sciences 2015;28(3):231-234
CountryChina
Language:English
Abstract: We investigated the protective effects of electromagnetic field (EMF) on the survival of the human renal proximal tubular cell line, HK-2, using an in vitro hypoxia/reoxygenation (H/R) injury model. The survival rate of cells cultured under H/R condition declined significantly, while the intracellular reactive oxygen species (ROS) levels markedly increased. The 10 Hz/1 mT EMF exposure reversed the H/R induced reduction in cell survival and induction of intracellular ROS. Our results suggest that 10 Hz/1 mT EMF exposure could inhibit H/R-induced cell death of HK-2 via suppression of intracellular ROS production and that this treatment might be clinically useful for the amelioration of renal ischemia/reperfusion injury.