Influence of canthaxanthin on D-galactose induced osseous changes of rat.
- Author:
Ling-peng PEI
1
;
Bo-di HUI
;
Fu-hui DONG
Author Information
- Publication Type:Journal Article
- MeSH: Alkaline Phosphatase; blood; Animals; Biomechanical Phenomena; Bone Density; drug effects; Bone and Bones; chemistry; drug effects; Calcium; analysis; Canthaxanthin; pharmacology; Galactose; toxicity; Male; Malondialdehyde; blood; Rats; Rats, Wistar; Superoxide Dismutase; blood
- From: China Journal of Orthopaedics and Traumatology 2008;21(8):613-616
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of canthaxanthin on D-galactose induced osseous changes of rat.
METHODSForty-five six-week-old Wistar male rats were randomly divided into model group, canthaxanthin group and young control group. In addition, 15 sixteen-month-old Wistar male rats were used as old control group. Model group and canthaxanthin group were given injections of D-galactose for 5 months (20 mg/kg/once per-day) to cause aging of rat. Then routine osseous parameters were tested and compared among the 4 groups.
RESULTSCompared with young control group, the BMD, parameters of structural mechanics and biomechanics, bone calcium, manganese, magnesium and the content of hydroxyproline in the model group decreased significantly (P < 0.01), however, the content of bone phosphorus, the activity of bone and serum ALP increased significantly (P < 0.01). Those changes of the model group were the same as the old control group,but the changes in the canthaxanthin group significantly differed with the model group (P < 0.01).
CONCLUSIONThe high does of D-galactose intake can cause aging and osteoporosis at the same time in rat, but canthaxanthin can prevent and inhibit D-galactose induced osseous changes.
