Protective effects of xuefu zhuyu decoction on myocardium ischemia reperfusion injury in rats.
- Author:
Danli TANG
1
;
Zhaihua LIU
;
Huamin ZHANG
;
Mingjie SUN
;
Yu SUI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Drugs, Chinese Herbal; therapeutic use; Humans; Interleukin-10; immunology; Interleukin-6; immunology; Male; Myocardial Reperfusion Injury; drug therapy; immunology; prevention & control; Protective Agents; therapeutic use; Random Allocation; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2010;35(22):3077-3079
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effects of Xuefu Zhuyu decoction on myocardium ischemia reperfusion injury in rats.
METHOD36 SD rats were divided into 3 groups randomly, sham-operated group, model group, Xuefu Zhuyu decoction group. The model of MI/RI of the myocardium was reproduced by ligation of left descending artery for 30 min followed by releasing the ligation for 2 hours in rats. Serum contents of LDH-L, CK were measured, the levels of serum IL-1beta, IL-6 and IL-10 were measured and myocardial ultrastructure at the ischemia region was observed under the transmission electron microscope after myocardial reperfusion injury.
RESULTCompared with model group, IL-1beta, IL-6 and IL-10 levels were lower, myocardial ultrastructural changes were improved in Xuefu Zhuyu decoction group (P < 0.01), however, serum contents of LDH-L and CK no significant difference were found among the model group and Xuefu Zhuyu decoction group.
CONCLUSIONXuefu Zhuyu decoction can protect myocardium from MI/RI, the mechanism of action was related to inhibiting inflammatory reaction and reducing arrhythmia and the injury of the myocardial ultrastructure.
