Regulation of ω-3 Fish Oil Emulsion on the SIRS during the Initial Stage of Severe Acute Pancreatitis
- Author:
XIONG JIONGXIN
1
;
ZHU SHIKAI
;
ZHOU YU
;
WU HESHUI
;
WANG CHUNYOU
Author Information
1. Department of Pancreatic Surgery,Union Hospital,Tongfi Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
- Keywords:
severe acute pancreatitis;
systemic inflammatory response syndrome;
ω-3 fish oil emul-sion;
pro-/anti-inflammatory cytokines;
parenteral supplementation
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2009;29(1):35-38
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to explore the effects of parenteral supplementation with ω-3 fish oil emulsion (Omegaven ) on systemic inflammatory response syndrome (SIRS) during the ini-tial stage of severe acute pancreatitis (SAP).In a prospective,randomized and controlled trial,60 pa-tients with SAP were randomized either to treat with conventional therapy (Con group,n=30) or conventional therapy plus intravenous supplementation with 0-3 fish oil emulsion 0.2 g/kg every day (FO group,n=30).The effects were analyzed by the SIRS-related indexes.The results showed that APACHE-II scores in FO group were significantly lower,and the gap increased much farther after the 4th day than those in Con group (P<0.05).Fluid equilibrium time became shorter markedly in FO group than in Con group (5.1±9.2 days vs 8.4±2.3 days).In FO group,SIRS scores were markedly duced,while IL-10 decreased markedly,most prominently between the 4th and 7th day,and the ratio euteral supplementation with ω-3 fish oil emulsion could efficiently lower the magnitude and persis-tence time of the SIRS,markedly retrieve the unbalance of the pro-/anti-inflammatory cytokines,im-prove severe condition of illness and may provide a new way to regulate the SIRS.
