The influence of spray drying process conditions on physical, chemical properties and lung inhaling performance of Panax notoginseng saponins - tanshinone II A composite particles.
- Author:
Hua-Mei WANG
1
;
Ting-Ming FU
;
Li-Wei GUO
Author Information
1. Key Laboratory of Separation Engineering for Chinese Medicine Compound, Nanjing University of Chinese Medicine, Nanjing 210029, China.
- Publication Type:Journal Article
- MeSH:
Administration, Inhalation;
Desiccation;
Diterpenes, Abietane;
administration & dosage;
chemistry;
isolation & purification;
Drug Compounding;
methods;
Dry Powder Inhalers;
methods;
Microscopy, Electron, Scanning;
Microspheres;
Panax notoginseng;
chemistry;
Particle Size;
Plants, Medicinal;
chemistry;
Saponins;
administration & dosage;
chemistry;
isolation & purification;
Solubility;
X-Ray Diffraction
- From:
Acta Pharmaceutica Sinica
2013;48(6):925-932
- CountryChina
- Language:Chinese
-
Abstract:
This study is to report the influence of conditions in spray drying process on physical and chemical properties and lung inhaling performance of Panax notoginseng Saponins - Tanshinone II A composite particles. According to the physical and chemical properties of the two types of components within the composite particles, three solvent systems were selected including ethanol, ethanol : acetone (9 : 1, v/v) and ethanol : acetone (4 : 1, v/v), and three inlet temperature: 110 degrees C, 120 degrees C, 130 degrees C to prepare seven different composite particle samples; each sample was characterized using laser diffraction, scanning electron microscopy (SEM), dynamic vapour sorption (DVS) and atomic force microscope (AFM), and their aerodynamic behavior was evaluated by a Next Generation Impactor (NGI). The results indicate that under the conditions of using the mixed solvent system of ethanol--acetone volume ratio of 9 : 1, and the inlet temperature of 110 degrees C, the resulting composite particles showed rough surface, with more tanshinone II A distributing in the outer layer, such composite particles have the best lung inhaling performance and the fine particle fraction (FPF) close to 60%. Finally it is concluded that by adjusting the conditions in co-spray drying process, the distribution amount and existence form of tanshinone II A in the outer layer of the particles can be changed so that to enhance lung inhaling performance of the drug composite particles.
