Differential expression of guanylin in colorectal cancer.
- Author:
Yin-bo CHEN
1
;
Yu-ping ZHU
;
Hai-yang FENG
;
Yong LIU
;
Jun QIAN
;
Yong-tian FAN
;
De-chuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Colorectal Neoplasms; metabolism; pathology; Female; Gastrointestinal Hormones; metabolism; Humans; Male; Middle Aged; Natriuretic Peptides; metabolism; Neoplasm Staging
- From: Chinese Journal of Gastrointestinal Surgery 2009;12(5):515-517
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of guanylin in colorectal cancer.
METHODSThe expression of guanylin was examined by RT-PCR and semiquantitative analysis in 20 cases of colorectal cancer, and its relationship with clinical characteristics was analyzed.
RESULTSThe positive expression of guanylin in normal tissue (80%, 16/20) was significantly higher than that in tumor tissue (35%, 7/20) (P<0.01). The same result was found in the semiquantitative analysis of 14 cases with differential expression. Differential expression of guanylin in colorectal cancer was associate with TNM stage (P<0.05), not with sex, Borrmann type and degree of differentiation (all P>0.05).
CONCLUSIONThere is differential expression of guanylin in colorectal cancer, and this kind of differential expression is associated with tumor TNM stage.
