Shal-type (Kv4.x) potassium channel pore blockers from scorpion venoms.
- Author:
Pierre Edouard BOUGIS
1
;
Marie-France MARTIN-EAUCLAIRE
2
Author Information
1. Aix-Marseille University, The National Center for Scientific Research (CNRS), Research Center for Neurobiology and Neurophysiology of Marseille UMR7286, 13344, Marseille, France. pierre-edouard.bougis@univ-amu.fr.
2. Aix-Marseille University, The National Center for Scientific Research (CNRS), Research Center for Neurobiology and Neurophysiology of Marseille UMR7286, 13344, Marseille, France.
- Publication Type:Journal Article
- MeSH:
Animals;
Potassium Channel Blockers;
chemistry;
Scorpion Venoms;
chemistry;
Scorpions;
Shal Potassium Channels;
antagonists & inhibitors
- From:
Acta Physiologica Sinica
2015;67(3):248-254
- CountryChina
- Language:English
-
Abstract:
Voltage-gated potassium channels (Kv4.1, Kv4.2 and Kv4.3) encoded by the members of the KCND/Kv4 (Shal) channel family mediate the native, fast inactivating (A-type) K(+) current (IA) described both in heart and neurons. This IA current is specifically blocked by short scorpion toxins that belong to the α-KTx15 subfamily and which act as pore blockers, a different mode of action by comparison to spider toxins known as gating modifiers. This review summarizes our present chemical and pharmacological knowledge on the α-KTx15 toxins.
