Expression of mRNA for membrane-type 1, 2, and 3 matrix metalloproteinases in human laryngeal cancer.
- Author:
Ya-nan SUN
1
,
2
;
Yuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Biomarkers, Tumor; analysis; Female; Gene Expression Regulation, Neoplastic; Humans; Laryngeal Neoplasms; metabolism; pathology; Larynx; metabolism; Lymphatic Metastasis; Male; Matrix Metalloproteinase 16; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; biosynthesis; genetics; Middle Aged; Neoplasm Invasiveness; RNA, Messenger; biosynthesis
- From: Chinese Medical Sciences Journal 2004;19(3):170-173
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate correlation of expressions of membrane-type 1, 2, and 3 matrix metalloproteinases (MT1, MT2, and MT3-MMP) to the invasion and metastases in laryngeal cancer.
METHODSReverse transcription-polymerase chain reaction (RT-PCR) was used to examine the mRNA level of MT1, MT2, and MT3-MMP in 24 patients with laryngeal cancer. The relationships of these three MT-MMP expressions to clinicopathology were analyzed by statistics.
RESULTSThe expressions of MT1, MT2, and MT3-MMP were significantly higher in laryngeal cancer tissues than those in para-tumorous tissues (P < 0.01) and had a close relationship with invasive depth (P < 0.05). But no significantly different expressions of these three MT-MMPs were found in different primary location and different histological grade of laryngeal cancer (P > 0.05). The expression of MT1-MMP was obviously higher in patients with metastatic lymph nodes than that in patients without metastatic lymph nodes (P < 0.05).
CONCLUSIONMT1, MT2, and MT3-MMP play an important role in the progression of laryngeal cancer, and MT1-MMP may serve as a reliable marker in estimating invasive and metastatic potency of laryngeal cancer. Suppressing expressions of MT1, MT2, and MT3-MMP early may inhibit the invasion and metastases of laryngeal cancer.
