Studies on anti-tumor metastatic constituents from Lindera glauca.
- Author:
Ran WANG
1
;
Shengan TANG
;
Huiyuan ZHAI
;
Hongquan DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemistry; isolation & purification; Antineoplastic Agents, Phytogenic; chemistry; isolation & purification; Aporphines; chemistry; isolation & purification; Benzylisoquinolines; chemistry; isolation & purification; Cell Line, Tumor; Chromatography, High Pressure Liquid; methods; Humans; Lindera; chemistry; Monoterpenes; chemistry; isolation & purification; Neoplasm Metastasis; prevention & control; Plant Extracts; chemistry; isolation & purification
- From: China Journal of Chinese Materia Medica 2011;36(8):1032-1036
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anti-tumor metastatic constituents from Lindera glauca.
METHODConstituent isolation and purification was carried by repeated column chromatography (silica gel, Toyopearl HW-40 and preparative HPLC). Their structures were elucidated on the basis of spectral data analysis. The anti-tumor metastasis assay was applied to evaluate the isolated compounds of their activities.
RESULTTen compounds (1 - 10) were isolated and their structures were identified by comparison of their spectral data with literature values as follows: Laurotetanine (1), N-methyllaurotetanine (2), reticuline (3), pallidine (4), N-trans-feruloyltyramine (5), N-cis-feruloyltyramine (6), atheroline (7), norisosocorydine (8), [9,9,9-(2) H3]-(1S*, 3S*, 4S*, 8S*)-p-menthane-3,8-diol (9), [9,9,9-(2) H3 ]-(1S*, 3R*, 4S*, 8S*)-p-Menthane-3,8-diol (10). Compounds 1, 2, 4, 5, 7 and 9 showed positive anti-tumor metastatic activities,and compounds 1, 4, and 5 showed significant anti-tumor metastatic activities.
CONCLUSIONCompound 3 was isolated from this plant for the first time. Compounds 9 and 10 were isolated from Lindera genus for the first time. Compounds 1, 4, and 5 showed significant anti-tumor metastatic activities.
