The effect of chronic intermittent hypoxia on p38MAPK in cerebral tissues of weanling rats.
- Author:
Yong-Hai ZHOU
1
;
Xiao-Hong CAI
;
Cun-Xue ZHANG
;
Shan-Shan JIA
;
Yong-Sheng GONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Hippocampus; enzymology; Hypoxia; enzymology; physiopathology; Male; Prefrontal Cortex; enzymology; RNA, Messenger; genetics; metabolism; Rats; Rats, Sprague-Dawley; Sleep Apnea Syndromes; physiopathology; p38 Mitogen-Activated Protein Kinases; genetics; metabolism
- From: Chinese Journal of Applied Physiology 2009;25(1):45-48
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effect of chronic intermittent hypoxia on p38MAPK in partial cerebral tissues of weanling rats.
METHODSRandomly, fifty male SD rats (3-week-old-4-week-old) were divided into five groups: 2-week-CIH group (2IH), 4-week-CIH group (4IH), 4-week-recovery group (4F), 2-week-control group (2C) and 4-week-control group (4C). Intermittent hypoxia model was induced by an intermittent hypoxia cabin. The expression of p38MAPK mRNA and the phosphorylation levels of p38MAPK (p-p38 protein) in the hippocampus and prefrontal cortex were measured by RT-PCR or Western blot respectively.
RESULTSNo matter in the hippocampus, or in the prefrontal cortex, the expression of p38MAPK mRNA and p-p38 protein in 2IH, 4IH and 4F groups were respectively higher than 2C and 4C groups (P < 0.05, respectively).
CONCLUSIONChronic intermittent hypoxia can activate the p38MAPK in partial cerebral tissues of weanling rats.
