Mechanism of the influence of CCE3 on bone mineral element metabolism in ovariectomized rats.
- Author:
Zhao-Qiang ZHANG
1
;
Hao-Yu LIU
;
Xi-Yi LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Density; drug effects; Estriol; analogs & derivatives; therapeutic use; Female; Follicle Stimulating Hormone; blood; Interleukin-6; blood; Luteinizing Hormone; blood; Osteoporosis; drug therapy; physiopathology; prevention & control; Ovariectomy; Quinestrol; analogs & derivatives; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2009;25(1):129-132
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the influence of CCE3 on bone mineral element metabolism and relative hormone in ovariectomized rats.
METHODS24 female SD rats were divided randomly into 4 groups (n = 6): (1) Normal control; (2) sham ovariectomy; (3) ovariectomy(OVX); (4) OVX + CCE3.
RESULTS(1) Ca, Mg, S, Co, Mn, Zn reduced obviously and P increased in the bone of the OVX rats. (2) E2, P, TSH, T4, CT, cortisol, GH reduced obviously and IL-6, FSH, LH increased obviously in serum of the OVX rats. (3) CCE3 corrected the changes of Ca, Mg, S, Co, Mn, Zn and P in bone as well as the changes of E2, P, TSH, T4, CT, cortisol, GH and IL-6, FSH, LH in serum of the OVX rats.
CONCLUSIONChanges of relative hormone and IL-6 induced by CCE3 are the important mechanism of the influence of CCE3 on bone mineral element metabolism in ovariectomized rats.
