Research progress on genome-wide association studies of colorectal cancer.
- Author:
Yan ZHANG
1
;
Maode LAI
;
Yimin ZHU
Author Information
1. Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Colorectal Neoplasms;
genetics;
Genetic Predisposition to Disease;
Genome-Wide Association Study;
Humans;
Polymorphism, Single Nucleotide
- From:
Journal of Zhejiang University. Medical sciences
2013;42(3):360-366
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer (CRC), one of the most common malignant tumors, is caused both by environmental and genetic factors. Genetic factor plays an important role in the pathogenesis of CRC. Genome-wide association study (GWAS) is a new tool of genetic research. A series of susceptibility genes and loci of the complex diseases has been identified with GWAS strategy. In this article, the research progress on GWAS of CRC is reviewed, and the advantages and limitations of GWAS study as well as the prospective of its application are discussed.
