Effects of jingqianshu granule on expression of 5-HT(1A)R of PMS model rats with liver-qi stagnation.

Author: Yunxiang SU ¹ ; Ling XUE
Author Information

1. Laboratory of Traditional Chinese Medicine Classical Theory, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China. suyunxiangben@hotmail.com
Publication Type:Journal Article
MeSH: Animals; Disease Models, Animal; Drugs, Chinese Herbal; pharmacology; therapeutic use; Female; Liver Diseases; drug therapy; metabolism; Premenstrual Syndrome; drug therapy; metabolism; Qi; Rats; Receptor, Serotonin, 5-HT1A; analysis
From: China Journal of Chinese Materia Medica 2011;36(24):3498-3501
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo research the effect of the Jingqianshu granule (JQS) on the expression of serotonin receptor-1A (5-HT(1A)R) in hippocampus and hypothalamus of premenstrual syndrome (PMS) model rats with Liver-qi depression.
METHODThe PMS model rats with Liver-qi depression were induced by bandaging the limbs. The model rats were treated with JQS, and evaluated by open-field test. The expression of 5-HT(1A)R in hippocampus and hypothalamus was analysed by the method of RT-PCR and Western blot.
RESULTAfter the JQS were administered, the open field scores, the expression of 5-HT(1A)R mRNA and protein in hippocampus and hypothalamus of rats increased significantly.
CONCLUSIONThe JQS granule can up-regulate the expression of 5-HT(1A)R in hippocampus and hypothalamus, which maybe one of the mechanism to treat PMS with liver-qi depression.