Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis
10.3321/j.issn:1002-0098.2008.07.009
- VernacularTitle:白细胞介素6基因-572位点多态性与重度慢性牙周炎易感性的相关分析
- Author:
Ze-Min GUAN
1
;
Jing-Jin LIU
;
Xin MA
;
Dong-Hong WU
;
Jie YU
;
Guo-Qiang HUANG
Author Information
1. 河南省人民医院
- Keywords:
Periodontitis;
Polymorphism,single nucleotide;
Interleukin-6
- From:
Chinese Journal of Stomatology
2008;43(7):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between interleukin-6(IL-6) gene -572C/G polymorphism and the risk of chronic periodontitis disease. Methods IL-6-572C/G genotype polymorphism was examined in 93 patients with chronic periodontitis and 96 control subjects by PCR restriction fragment length polymorphism(PCR-RFLP) method. Results IL-6-572GG genotype and G allele were more frequent in chronic periodontitis patients than that in control subjects (P < 0. 05). -572CC, CG and GG genotype frequency were 52.7%, 40. 9 %, 6.4 % in chronic periodontitis patients and 67.7 %, 31.3%, 1.0 % in control subjects, respectively. -572CG + GG geuotype and G allele were more frequent in patients than that in control subjects (P < 0. 05). Compared with CC genotype, the odds ratio for chronic periodontitis was 1.88(95% CI: 1.04-3.40, P<0.05) for CG+GG genotype. Conclusions The frequency of-572CG+GG genotype was higher in patients with chronic periodontitis compared with the control subjects. IL-6-572C/G polymorphism may be a genetic susceptibility factor for chronic periodontitis in Chinese Hans population.
