Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues.
- Author:
Zhi-song PIAO
1
;
Ya-bing FENG
;
Lin WANG
;
Xing-quan ZHANG
;
Mao LIN
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Anti-HIV Agents;
isolation & purification;
pharmacology;
Cells, Cultured;
Drugs, Chinese Herbal;
isolation & purification;
pharmacology;
Gnetum;
chemistry;
HIV-1;
drug effects;
physiology;
Inhibitory Concentration 50;
Leukocytes, Mononuclear;
cytology;
virology;
Molecular Structure;
Plants, Medicinal;
chemistry;
Stilbenes;
chemical synthesis;
chemistry;
isolation & purification;
pharmacology;
Virus Replication;
drug effects
- From:
Acta Pharmaceutica Sinica
2010;45(12):1509-1515
- CountryChina
- Language:Chinese
-
Abstract:
Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1. Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication. Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 micromol x L(-1).
