Prenatal diagnosis of sirenomelia by two-dimensional and three-dimensional skeletal imaging ultrasound.
10.1007/s11596-015-1530-2
- Author:
Rong LIU
1
,
2
;
Xin-lin CHEN
3
;
Xiao-hong YANG
4
;
Hui-jing MA
5
Author Information
1. Deparment of Medical Ultrasound, Hubei Maternal and Children Health Hospital, Wuhan, 430070, China. stream0917@
2. com.
3. Deparment of Medical Ultrasound, Hubei Maternal and Children Health Hospital, Wuhan, 430070, China. 928339431@qq.com.
4. Deparment of Medical Ultrasound, Hubei Maternal and Children Health Hospital, Wuhan, 430070, China.
5. Department of Computerized Tomography, Wuhan Children's Hospital, Wuhan, 430015, China.
- Publication Type:Journal Article
- Keywords:
sirenomelia;
three-dimensional helical computed tomography;
three-dimensional skeletal imaging ultrasound
- MeSH:
Adult;
Ectromelia;
diagnostic imaging;
Female;
Humans;
Pregnancy;
Ultrasonography, Prenatal;
Young Adult
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2015;35(6):928-931
- CountryChina
- Language:English
-
Abstract:
This study sought to evaluate the contribution of two-dimensional ultrasound (2D-US) and three-dimensional skeletal imaging ultrasound (3D-SUIS) in the prenatal diagnosis of sirenomelia. Between September 2010 and April 2014, a prospective study was conducted in a single referral center using 3D-SUIS performed after 2D-US in 10 cases of sirenomelia. Diagnostic accuracy and detailed findings were compared with postnatal three-dimensional helical computed tomography (3D-HCT), radiological findings and autopsy. Pregnancy was terminated in all 10 sirenomelia cases, including 9 singletons and 1 conjoined twin pregnancy, for a total of 5 males and 5 females. These cases of sirenomelia were determined by autopsy and/or chromosomal examination. Initial 2D-US showed that there were 10 cases of oligohydramnios, bilateral renal agenesis, bladder agenesis, single umbilical artery, fusion of the lower limbs and spinal abnormalities; 8 cases of dipus or monopus; 2 cases of apus; and 8 cases of cardiac abnormalities. Subsequent 3D-SUIS showed that there were 9 cases of scoliosis, 10 cases of sacrococcygeal vertebra dysplasia, 3 cases of hemivertebra, 1 case of vertebral fusion, 3 cases of spina bifida, and 5 cases of rib abnormalities. 3D-SUIS identified significantly more skeletal abnormalities than did 2D-US, and its accuracy was 79.5% (70/88) compared with 3D-HCT and radiography. 3D-SUIS seems to be a useful complementary method to 2D-US and may improve the accuracy of identifying prenatal skeletal abnormalities related to sirenomelia.
