Expression and clinical significance of IL-17 and IL-17 receptor in ulcerative colitis.
10.1007/s11596-016-1538-2
- Author:
Heng ZHANG
1
;
Bing XIA
2
;
Jin LI
2
;
Qiu ZHAO
2
;
Zhi-tao CHEN
3
;
Rui ZHOU
2
;
Jie WU
2
;
Author Information
1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University; Clinical Research Center for Intestinal & Colorectal Diseases of Hubei Province, and Key Laboratory of Allergy and Immune-related Diseases, Wuhan, 430071, China. 653262549@qq.com.
2. Department of Gastroenterology, Zhongnan Hospital of Wuhan University
3. Department of Gastroenterology, the Central Hospital of Wuhan, Wuhan, 430014, China.
- Publication Type:Journal Article
- Keywords:
interleukin-17;
interleukin-17 receptor;
intestinal mucosa;
serum;
ulcerative colitis
- MeSH:
Adult;
Biomarkers;
blood;
C-Reactive Protein;
metabolism;
Case-Control Studies;
Colitis, Ulcerative;
blood;
pathology;
Female;
Humans;
Interleukin-17;
blood;
Male;
Middle Aged;
RNA, Messenger;
blood;
Receptors, Interleukin-17;
genetics;
metabolism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2016;36(1):37-40
- CountryChina
- Language:English
-
Abstract:
The purpose of this study was to determine the expression levels of IL-17 in serum and IL-17 receptor (IL-17R) in intestinal mucosa tissue in patients with ulcerative colitis (UC) and controls, and evaluate their relationship with disease activity and explore the role of IL-17 in the patho-genesis of UC. A total of 36 Chinese UC patients and 60 healthy controls were enrolled in this study. Serum IL-17 and C-reactive protein (CRP) levels were determined by ELISA and immunonephelometry, respectively. The IL-17R mRNA expression levels were detected by quantitative PCR. Serum IL-17 levels were significantly elevated in UC patients as compared with those in the healthy controls (P<0.05). Among UC patients, serum IL-17 levels were significantly increased in active phase as compared with those in inactive phase (P<0.05), and correlated with CRP levels (r=0.578, P<0.01). IL-17R expression levels were higher in active UC patients than in healthy controls (P<0.05). It was concluded that IL-17 levels were highly expressed in UC, especially in active phase, and correlated with CRP levels in UC patients.
