Significant positive correlation of plasma BPDE-albumin adducts to urinary 1-hydroxypyrene in coke oven workers.
- Author:
Hong WANG
1
;
Xiao-Bo YANG
;
Ai-Lin LIU
;
Hong-Yan ZHEN
;
Liang GUO
;
Hua-Shan LIANG
;
Yong-Yi BI
;
Yun BAI
;
Yong-Wen CHEN
;
Tang-Chun WU
Author Information
- Publication Type:Journal Article
- MeSH: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; analysis; Adult; Coal Mining; manpower; Coke; adverse effects; Environmental Monitoring; Humans; Male; Mutagens; analysis; Occupational Exposure; Plasma; chemistry; Polycyclic Aromatic Hydrocarbons; Pyrenes; analysis; Serum Albumin; analysis; Urinalysis; Urine; chemistry
- From: Biomedical and Environmental Sciences 2007;20(3):179-183
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the application of BPDE-albumin adducts as monitoring biomarkers for coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to explore possible relationship between BPDE-albumin adducts and urinary 1-hydroxypyrene (1-OHP) levels in them.
METHODSThirty-seven coke oven workers from a coke plant and 47 controls without the occupational exposure to PAHs were recruited in this study. The levels of plasma BPDE-albumin adducts and urinary 1-OHP were analyzed using high performance liquid chromatography.
RESULTSThe median levels of BPDE-albumin adducts (42.10 fmol/mg albumin) and urinary 1-OHP (5.46 micromol/mol creatinine) were significantly higher in coke oven workers than in controls (14.16 fmol/mg albumin, 2.96 micromol/mol creatinine, respectively; P<0.01). Multiple logistic regression analysis showed that coke oven workers were at higher risk of having BPDE-albumin adduct levels above 25.30 micromol/mg albumin (OR=1.79, P<0.01) and urinary 1-OHP levels above 4.13 micromol/mol creatinine (OR=2.45, P<0.05). There was a positive correlation between the levels of BPDE-albumin adducts and urinary 1-OHP in all subjects (rs=0.349, P<0.01).
CONCLUSIONBPDE-albumin adduct is a useful biomarker for monitoring long-term exposure to PAHs, and plasma BPDE-albumin adducts level is significantly correlated to urinary 1-OHP levels in coke oven workers.
