Apolipoprotein E genotypes and carotid artery atherosclerosis in type 2 diabetes mellitus.
- Author:
Guang-da XIANG
1
,
2
;
Tai-hong HU
;
Yun-lin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Analysis of Variance; Apolipoprotein E4; Apolipoproteins E; genetics; Arteriosclerosis; pathology; Body Mass Index; Carotid Artery Diseases; pathology; Cholesterol; blood; Cholesterol, LDL; blood; Diabetes Mellitus, Type 2; blood; genetics; pathology; Female; Gene Frequency; Genotype; Glycated Hemoglobin A; metabolism; Humans; Lipoprotein(a); blood; Male; Middle Aged; Smoking; Triglycerides; blood; Tunica Intima; pathology; Tunica Media; pathology
- From: Chinese Journal of Medical Genetics 2003;20(1):66-68
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between carotid artery intima media thickness (IMT) and apolipoprotein (Apo) E gene polymorphisms in type 2 diabetes mellitus (DM2).
METHODSTwo hundred and fifty-five DM2 patients without angiopathy and 107 healthy individuals were selected. PCR/allele-specific oligonucleotide probe was used to determine their apoE genotypes.
RESULTSThe prevalence distribution of apoE genotypes and alleles in DM2 patients and that in controls were similar. The TC, LDL-C and Lp(a) concentrations in e4/4, e4/3 subgroups were significantly higher than those in e3/2, e2/2 subgroups (P<0.05). The average value of IMT in e4/4 e4/3 carriers (0.89 mm) was significantly greater than that in e3/2 e2/2 carriers (0.62 mm) (P<0.05). After adjustment for TC, LDL-C, TG, Lp(a), FBG, HbA1c, age, BMI, and smoking, ANCOVA showed that the average value of carotid IMT was significantly greater in subjects with e4/4 e4/3, compared with that in subjects with e3/2 e2/2(P=0.033).
CONCLUSIONApo e4 allele increases the risk for carotid artery atherosclerosis in the early stage of diabetic population.
