Clinical and experimental studies on five cases of acute myeloid leukemia with translocation t(16;21)(p11;q22).

Yafang WU; Yongquan XUE; Jinlan PAN; Qinfeng MA

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Clinical and experimental studies on five cases of acute myeloid leukemia with translocation t(16;21)(p11;q22).

Author: Yafang WU ^{1
,

2} ; Yongquan XUE ; Jinlan PAN ; Qinfeng MA
Author Information

1. The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu, 215006 P. R. China. uujihsmc@public
2. sz.js.cn
Publication Type:Case Reports
MeSH: Acute Disease; Adolescent; Adult; Cells, Cultured; Child; Chromosomes, Human, Pair 16; genetics; Chromosomes, Human, Pair 21; genetics; Female; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Leukemia, Myeloid; genetics; Male; Translocation, Genetic
From: Chinese Journal of Medical Genetics 2003;20(2):171-173
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo report five cases of acute myeloid leukemia (AML) with t(16;21)(p11;q22) translocation and the result of chromosome painting analysis on one of them.
METHODSChromosome specimens were prepared by short-term culture of bone marrow cells. Karyotype analysis was made by R-banding technique. Chromosome painting was performed using whole chromosome probes 16 and 21 in 1 case.
RESULTSKaryotype analysis showed identical translocation t(16;21)(p11;q22) in all five cases, accounting for 0.3% of 1448 cases of acute myeoid leukemia examined in the past fifteen years. Moreover, chromosome painting distinctly demonstrated t(16;21) in one of them. Leukemia blasts did not show hemophagocytosis in all of them.
CONCLUSIONt(16;21) translocation is a rare and recurring chromosome rearrangement. It represents a specific type of AML. Chromosome painting technique is a more reliable means for detecting it, compared with the conventional karyotype analysis.