Association of copy number variation of exon 11 of IL-23 receptor gene with susceptibility to tuberculosis among Chinese Uygurs.
- VernacularTitle:新疆维吾尔族人群白介素-23受体基因拷贝数变异与结核病易感性的相关性
- Author:
Daobin JIANG
1
;
Xin HU
;
Shuang LI
;
AbuduJilili JULAITI
;
Yu XIA
;
Jing WANG
;
Wenbao ZHANG
;
Qimanguli WUSHOUER
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; ethnology; genetics; Case-Control Studies; China; ethnology; DNA Copy Number Variations; Exons; Female; Genetic Predisposition to Disease; ethnology; Humans; Male; Middle Aged; Receptors, Interleukin; genetics; Tuberculosis, Pulmonary; ethnology; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2016;33(1):97-100
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of copy number variations (CNVs) of exon 11 of IL-23 receptor gene with susceptibility to active pulmonary tuberculosis among Chinese Uygurs.
METHODSIn this study, 250 subjects with active pulmonary tuberculosis (PTB) and 250 normal controls were recruited. A paired case-control study was conducted in the Chinese Uygur population in Xinjiang and the CNV of IL-23R was analyzed using Taqman real-time PCR.
RESULTSThe study showed that the frequencies of different copy number in exon 11 of IL-23R between PTB and control groups were statistically significant (χ(2)=13.35, P<0.01). There were significant difference in CNV of exon 11 in IL-23R between PTB patients and controls (χ(2)=14.95, P<0.01, OR=2.875, 95%CI: 1.655-4.994). The increase of copy number in exon 11 of IL-23R showed significantly different between PTB and control groups (χ(2)=10.475, P=0.0012, OR=2.611, 95%CI: 1.437-4.744).
CONCLUSIONThe CNV of exon 11 in IL-23R is associated with PTB in the Chinese Uygur population. The increase of the copy number in exon 11 of IL-23R may be a risk factor for PTB in Chinese Uygurs.
