A Case of Interstitial Pneumonitis Associated with Sirolimus Treatment in Renal Transplantation Recipient.
- Author:
Ji Young LEE
1
;
Sun Young KIM
;
Seung Woon BYUN
;
Young Sun YEO
;
Jai Won CHANG
;
Won Seok YANG
;
Soon Bae KIM
;
Jung Sik PARK
;
Su Kil PARK
Author Information
1. Department of Internal Medicine, ASAN Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. skpark@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Sirolimus;
Kidney transplantation;
Pneumonitis;
Adverse effects
- MeSH:
Calcineurin;
Dyspnea;
Humans;
Kidney Transplantation;
Lung Diseases, Interstitial;
Male;
Pneumonia;
Sirolimus;
Thorax
- From:Korean Journal of Nephrology
2008;27(5):611-615
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sirolimus is a promising immunosuppressive drug for renal transplantation to avoid nephrotoxicity of calcineurin inhibitor. However, it has been associated with uncommon but, important pulmonary toxicity. We present a case of sirolimus related dyspnea with abnormal chest radiographic finding in a 63 year old male renal transplantation recipient. There was no evidence of bacterial, fungal, or viral infection. Dose reduction of sirolimus resulted in a significant improvement of the symptoms and chest radiographic finding.
