Study advancement of calpain and apoptosis following cerebral ischemia.
- Author:
Jian LIU
1
;
Junfeng XU
;
Guangjun WANG
;
Mingxing YANG
;
Lin GUO
Author Information
1. Institue of Acupuncture and Moxibustion, Frist Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
drug effects;
Brain Ischemia;
drug therapy;
metabolism;
Calcium-Binding Proteins;
therapeutic use;
Calpain;
antagonists & inhibitors;
metabolism;
physiology;
Humans
- From:
Journal of Biomedical Engineering
2009;26(5):1150-1153
- CountryChina
- Language:Chinese
-
Abstract:
Calpains, calcium-activated cysteine proteases with a neutral pH optimum, lead to degration of cystoskeletion and structural protein, and delayed neuronal death. The activation of calpains contribute to apoptosis. Calpain inhibitors provide a novel and potential treatment for cerebral ischemia due to improvement of cerebral infarct and ischemia.
