Outcome post orthotopic heart transplantation for patients with end-stage hypertrophic cardiomyopathy
10.3760/cma.j.issn.0253-3758.2011.02.006
- VernacularTitle:肥厚型心肌病原位心脏移植后心肌再肥厚初探
- Author:
Xue-Shan HUANG
1
;
Liang-Wan CHEN
;
Yu-Chen PAN
;
Feng LIN
;
Qi-Min WANG
;
Zhong-Yao HUANG
;
Han-Fan QIU
;
Hua CAO
;
Gui-Can ZHANG
;
Dao-Zhong CHEN
Author Information
1. 福建医科大学附属协和医院
- Keywords:
Heart transplantation;
Cardiomyopathy,hypertrophic;
Immune tolerance;
Embolism cholesterd
- From:
Chinese Journal of Cardiology
2011;39(2):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the outcome of orthotopic heart transplantation for patient with end-stage hypertrophic cardiomyopathy. Methods This retrospective review analyzed the clinical data of nine patients (7 males ) undergoing orthotopic heart transplantation for end-stage hypertrophic cardiomyopathy in our center. All patients received induced therapy protocols peri-operative and standard triple maintenance immunosuppressive therapy postoperative. Results One recipients developed acute renal failure due to renal artery embolism and allograft rejection in the early posttransplantive course, symptoms and signs were improved under continuous renal replacement therapy and steroid-pulse therapy, this patient died of sudden cardiac arrest at 32 months post transplantation. Another recipient developed demyelinating disease in frontal and parietal lobe and finally recovered with medical therapy. Eight patients survived the operation with good quality of life and there was no episode of rejection or infection or chronic graft arteriosclerosis during follow-up time. Three recipients developed left ventricular hypertrophy and there were no signs of grapg-vessle diseases in the survivals. Conclusion Heart transplantation is the best therapeutic option for selected patients with end-stage hypertrophic cardiomyopathy.
