Progress in fungal polyketide biosynthesis.

Author: Xiwei CHEN ¹ ; Meng XU ¹ ; Cheng FENG ¹ ; Changhua HU ¹
Author Information

1. Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Publication Type:Journal Article
Keywords: biosynthesis; enzymatic catalysis; fungal polyketide; gene cluster; natural products
From: Chinese Journal of Biotechnology 2018;34(2):151-164
CountryChina
Language:Chinese
Abstract: Fungal polyketides display complex structures and variously biological activities. Their biosynthetic pathways generally contain novel enzyme-catalyzed reactions. This review provides a summary of recent research advances in molecular mechanism of the biosynthesis of fungal polyketides including highly-reducing polyketide synthases (HR-PKSs), non-reducing polyketide synthases (NR-PKSs), as well as polyketide-nonribosomal peptide synthase (PKS-NRPSs) and reducingnon- reducing polyketide synthase (HR-NR PKSs) hybrids. The elucidation of biosynthetic mechanism of many fungal polyketides provides guidance on the discovery of new biosynthetic gene cluster of fungal polyketide natural products and compounds with novel structures as well as their analogue.