Gene expression in patients with myelodysplastic syndrome.
- Author:
Bao-An CHEN
1
;
Bo ZHANG
;
Chong GAO
;
Feng GAO
;
Guo-Hua XIA
;
Ze-Ye SHAO
;
Jia-Hua DING
;
Gang ZHAO
;
Jian CHEN
;
Jun WANG
;
Hui-Hui SONG
;
Wen BAO
;
Yue-Jiao ZHONG
;
Xiao-Ping PEI
;
Fei WANG
;
Zhong-Ze GU
Author Information
1. Department of Hematology, Zhongda Hospital, Southeast University Medical College, Nanjing 210009, Jiangsu Province, China. cba8888@hotmail.com
- Publication Type:Journal Article
- MeSH:
Aged;
Bone Marrow Cells;
metabolism;
CASP8 and FADD-Like Apoptosis Regulating Protein;
genetics;
metabolism;
Case-Control Studies;
Female;
Gene Expression;
Humans;
Intercellular Signaling Peptides and Proteins;
genetics;
metabolism;
Male;
Membrane Proteins;
genetics;
metabolism;
Myelodysplastic Syndromes;
genetics;
RNA, Messenger;
genetics
- From:
Journal of Experimental Hematology
2010;18(3):666-670
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the expression of c-FLIPL, c-FLIPS and DLK1 mRNA in the patients with myelodysplastic syndrome (MDS) and its clinical significance. The mRNA expression of c-FLIPL, c-FLIPS and DLK1 in bone marrow mononuclear cells (BMMNC) of 16 patients with MDS and 3 controls were detected by RT-PCR. The results indicated that the expression of DLK1 mRNA was up-regulated in MDS, including RA and RAEB, as compared with controls (p < 0.05). There was no significant difference in expression of DLK1 between RA and RAEB patients (p > 0.05); the expression of c-FLIPL mRNA both in RA and RAEB patients was higher than that in controls (p < 0.05). There was no significant difference in expression of c-FLIPL between RA and RAEB patients (p > 0.05); the expression of c-FLIPS mRNA was not significantly different between MDS patients and controls (p > 0.05), but its expression in RAEB patients was significantly higher as compared with RA patients and controls (p < 0.05). It is concluded that the mRNA expressions of DLK1, c-FLIPL and c-FLIPS in MDS patients are abnormal, some of which may be useful as an important indicator for the evaluation of development in MDS.
