Transitional CK19 positive cells-a new possible marker of hepatic precancerous lesion.
- Author:
Yu CHEN
1
;
Zhong-ping DUAN
;
Bao-en WANG
;
Ji-dong JIA
;
Guang-yong CHEN
;
Yi-mei LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Biomarkers, Tumor; Female; Humans; Keratins; analysis; Liver Neoplasms; chemistry; pathology; Male; Middle Aged; Precancerous Conditions; chemistry; pathology; Tomography, X-Ray Computed; alpha-Fetoproteins; analysis
- From: Chinese Journal of Hepatology 2004;12(1):38-39
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between Transitional CK19 positive cells and hepatic precancerous lesion in chronic hepatitis B patients.
METHODSWe observed the expression of CK19 in liver tissue of chronic hepatitis B patients by LSAB immunohistochemical staining, and examined serum AFP and ultrasonography one time per 3 months for one year.
RESULTSWe observed a population of CK19 positive cells-with size and structure between those of human oval cells and mature hepatocytes-that usually occurred along with oval-cell proliferation. It was suggested that these transitional cells may partly account for the elevation of serum AFP. One patient occurred hepatic carcinoma, another patient had low-echogenic nodules in liver parenchyma within the 1 year follow-up period.
CONCLUSIONTransitional CK19 positive cells could be regarded as a new possible pathological marker of hepatic precancerous lesion.
