Gliofibroma: A Case Report and Review of the Literature.
10.3346/jkms.2003.18.4.625
- Author:
Yoonjung KIM
1
;
Yeon Lim SUH
;
Changohk SUNG
;
Seung Chyul HONG
Author Information
1. Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ylsuh@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Astrocytoma;
Fibroma;
Glioma;
Brain Neoplasms
- MeSH:
Adult;
Astrocytoma/*diagnosis/pathology;
Brain Neoplasms/*diagnosis/pathology;
Glial Fibrillary Acidic Protein/biosynthesis;
Human;
Immunohistochemistry;
Male;
Mitosis;
Necrosis;
Prognosis;
Seizures/complications;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2003;18(4):625-629
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gliofibroma is a rare astrocytic tumor, composed of a glial component ranging from benign to high grade of malignancy and a consistently benign mesenchymal component. Its exact biological behavior is not fully known. In addition, histogenesis and prognostic factors are also still debatable. We herein present a rare case of gliofibroma in a 25-yr-old male with seizure. A computed tomographic scan of the brain showed a 1.5 cm-sized, enhancing mass with calcification. Histologically, the tumor consisted of glial fibrillary acidic protein (GFAP)-positive glial cells admixed with a mesenchymal component and extensive collagen lay down. The glial cells displayed variable cellularity, but without mitosis or necrosis. Since the MIB-1 labeling index was up to 35.8% in the cellular areas of the glial component, it could be considered to be a predictor of worse prognosis.
