Impact analysis of shuxuetong injection on abnormal changes of ALT based on generalized boosted models propensity score weighting.

Wei YANG; Dan-Hui YI; Yan-Ming XIE; Wei YANG; Yi DAI; Ying-Jie ZHI; Yan ZHUANG; Hu YANG

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Impact analysis of shuxuetong injection on abnormal changes of ALT based on generalized boosted models propensity score weighting.

Author: Wei YANG ¹ ; Dan-Hui YI ² ; Yan-Ming XIE ³ ; Wei YANG ³ ; Yi DAI ² ; Ying-Jie ZHI ³ ; Yan ZHUANG ⁴ ; Hu YANG ²
Author Information

1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. yangyxq@ruc.edu.cn
2. Statistical Institute of Renmin University, Beijing 100872, China.
3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
4. The PL4 Navy General Hospital, Beijing 100048, China.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; metabolism; Child; Drug Therapy; Drugs, Chinese Herbal; administration & dosage; adverse effects; Female; Hospital Information Systems; statistics & numerical data; Humans; Liver; drug effects; enzymology; Logistic Models; Male; Middle Aged; Pragmatic Clinical Trials as Topic; Propensity Score; Retrospective Studies; Young Adult
From: China Journal of Chinese Materia Medica 2013;38(18):3039-3047
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo estimate treatment effects of Shuxuetong injection on abnormal changes on ALT index, that is, to explore whether the Shuxuetong injection harms liver function in clinical settings and to provide clinical guidance for its safe application.
METHODClinical information of traditional Chinese medicine (TCM) injections is gathered from hospital information system (HIS) of eighteen general hospitals. This is a retrospective cohort study, using abnormal changes in ALT index as an outcome. A large number of confounding biases are taken into account through the generalized boosted models (GBM) and multiple logistic regression model (MLRM) to estimate the treatment effects of Shuxuetong injections on abnormal changes in ALT index and to explore possible influencing factors.
RESULTThe advantages and process of application of GBM has been demonstrated with examples which eliminate the biases from most confounding variables between groups. This serves to modify the estimation of treatment effects of Shuxuetong injection on ALT index making the results more reliable.
CONCLUSIONBased on large scale clinical observational data from HIS database, significant effects of Shuxuetong injection on abnormal changes in ALT have not been found.