Based on hospital information system data, analysis of effects of different doses of shenmai injection on renal function.

Jun-Jie JIANG; Hao TANG; Yan-Ming XIE; Hu YANG; Yan ZHUANG

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Based on hospital information system data, analysis of effects of different doses of shenmai injection on renal function.

Author: Jun-Jie JIANG ^{1
,

2} ; Hao TANG ³ ; Yan-Ming XIE ⁴ ; Hu YANG ³ ; Yan ZHUANG ⁵
Author Information

1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. studentjiangjunjie@
2. com
3. Renmin University of China, Beijing 100872, China.
4. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
5. The PLA Navy General Hospital, Beijing 100048, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Aged, 80 and over; Blood Urea Nitrogen; Case-Control Studies; Creatinine; blood; Drug Dosage Calculations; Drugs, Chinese Herbal; administration & dosage; adverse effects; Female; Hospital Information Systems; statistics & numerical data; Humans; Kidney; drug effects; metabolism; physiopathology; Male; Middle Aged; Pragmatic Clinical Trials as Topic; Propensity Score; Retrospective Studies; Urea; blood; Young Adult
From: China Journal of Chinese Materia Medica 2013;38(18):3060-3067
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo assess whether the dosage of Shenmai injection influences renal function.
METHODAnalysis of hospital information system (HIS) data from 18 national hospitals using Shenmai injections. Patients were aged between 18 to 80 years old. Blood analysis of creatinine and serum urea nitrogen was undertaken 7 days before and after exceeding the maximum recommended dose of 100 mL of Shenmai injection. Propensity score method was used to compare the differences between the two groups of renal function scores.
RESULTThe differences in abnormal changes in creatinine and serum urea nitrogen levels between the groups before and after exceeding the recommended dose was not statistically significant, but abnormal changes were detected.
CONCLUSIONBased on the available data we did not find that exceeding the recommended dose of Shenmai injection had a significantly deleterious effect on renal function. However, caution should be applied in its clinical use.