Expression and clinical significance of IL-17 and IL-21 in patients with acute leukemia.
- Author:
Mei-Fang SU
1
;
Chang-Feng WANG
;
Yong-Mei ZHAO
;
Ji-Xiong WU
;
Yao ZHANG
Author Information
1. Department of Hematology, Huanggang Central Hospital, Huanggang 438000, Hubei Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
CD4-Positive T-Lymphocytes;
Case-Control Studies;
Female;
Humans;
Interleukin-17;
metabolism;
Interleukins;
metabolism;
Leukemia, Myeloid, Acute;
metabolism;
Male;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
metabolism;
Th17 Cells;
secretion;
Young Adult
- From:
Journal of Experimental Hematology
2010;18(5):1143-1146
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the effects of peripheral blood Th17 cells, IL-17 and IL-21 in the occurrence and development of acute leukemia. 60 patients with acute leukemia (19 patients with ALL, 41 patients with AML) were divided into non-remission group (group A, n=24), remission group (group B, n=36); 25 healthy volunteers were used as control group (group C). In addition to this, these 60 patients were divided into infection group (n=32) and non-infection group (n=28) on the basis of infection status. The concentration of IL-17 and IL-21 in the peripheral blood mononuclear cell culture supernatant after stimulation with anti-CD3 and anti-CD28 mAb were determined with ELISA. The expression of CD4+ IL-17+ cells was determined by flow cytometry. The results showed that (1) the concentrations of IL-17 and IL-21, and proportion of Th17 cells in group A and group B were much lower than those in group C (p<0.05); (2) the expression levels of IL-17 and IL-21, and the proportion of Th17 cells in group A were lower than those in group B (p<0.05); (3) the expression levels of Th17 and IL-17 in infection group were lower than those in non-infection group (p<0.05). It is concluded that Th17 cells may play important roles in the occurrence and development of acute leukemia through secreting IL-17 and IL-21, and their functional level can partially reflect the status of leukemia and can be used to evaluate the risks of infection in patients with leukemia.
