Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients.
10.3346/jkms.2015.30.8.1042
- Author:
Ga Young BAN
1
;
Young Min YE
;
Yunhwan LEE
;
Jeong Eun KIM
;
Young Hee NAM
;
Soo Keol LEE
;
Joo Hee KIM
;
Ki Suck JUNG
;
Sang Ha KIM
;
Hae Sim PARK
Author Information
1. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr
- Publication Type:Clinical Trial ; Original Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
Elderly;
Asthma;
Control;
Performance;
Comorbidity
- MeSH:
Aged;
Aged, 80 and over;
Anti-Asthmatic Agents/*administration & dosage;
Asthma/*diagnosis/epidemiology/*therapy;
Critical Pathways/statistics & numerical data;
Dose-Response Relationship, Drug;
Female;
Geriatric Assessment/*methods/statistics & numerical data;
Humans;
Male;
Middle Aged;
Outcome Assessment (Health Care)/*methods;
*Quality of Life;
Reproducibility of Results;
Republic of Korea/epidemiology;
Sensitivity and Specificity;
Treatment Outcome
- From:Journal of Korean Medical Science
2015;30(8):1042-1047
- CountryRepublic of Korea
- Language:English
-
Abstract:
The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged > or = 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improved asthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 +/- 3.3 in the improved vs. 4.5 +/- 4.4 in the control) and higher physical functioning (PF) scale (89.8 +/- 14.2 in the improved vs. 82.0 +/- 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of < or = 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessing asthma control in elderly asthmatic patients.
