Progress in genetic study of aortic dissection.
10.3760/cma.j.issn.1003-9406.2013.04.012
- VernacularTitle:主动脉夹层相关基因的研究进展
- Author:
Yong-sheng LI
1
;
Wei-guo FU
;
Zhi-hui DONG
;
Li-xin WANG
;
Yu-qi WANG
Author Information
1. Department of Vascular Surgery, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai 200032, P. R. China. fu.weiguo@zs-hospital.sh.cn.
- Publication Type:Journal Article
- MeSH:
Aneurysm, Dissecting;
genetics;
Aortic Aneurysm;
genetics;
Humans;
Mutation;
Polymorphism, Genetic
- From:
Chinese Journal of Medical Genetics
2013;30(4):435-438
- CountryChina
- Language:Chinese
-
Abstract:
Genetic study can provide important insight into the etiology of aortic dissection. To explore the pathogenesis and natural history of aortic dissection, a number of genes have been identified through microarray chip screening and undergone testing of polymorphisms to find mutations strongly associated with the disease. The results suggested aortic dissection to be a multi-gene disorder. Multiple genes probably work together to promote its development. Several diseases with a genetic predisposition are closely connected with aortic dissection, which also implied a role of genetic changes and malfunction in this disease.
