The development of co-amorphous drug systems.
- Author:
Jing YAO
1
;
Nian-Qiu SHI
;
Xing-Lin WANG
Author Information
1. Pharmaceutical College of Henan University, Kaifeng 475001, China.
- Publication Type:Journal Article
- MeSH:
Calorimetry, Differential Scanning;
Chemistry, Pharmaceutical;
methods;
Cimetidine;
chemistry;
Drug Combinations;
Drug Compounding;
Drug Stability;
Glipizide;
chemistry;
Indomethacin;
chemistry;
Naproxen;
chemistry;
Ranitidine;
chemistry;
Simvastatin;
chemistry;
Solubility;
Spectroscopy, Fourier Transform Infrared;
Spectrum Analysis, Raman;
Technology, Pharmaceutical;
methods;
Temperature;
X-Ray Diffraction
- From:
Acta Pharmaceutica Sinica
2013;48(5):648-654
- CountryChina
- Language:Chinese
-
Abstract:
Converting two poorly water-soluble crystalline drugs to co-amorphous drug systems by ball milling, quench-cooling, or cryo-milling method can improve stability of the drug, enhance dissolution rates, and reduce adverse reactions of the single drug. Co-amorphous system has been used to solve problems of co-administration of medicines. Formation and intermolecular interactions of co-amorphous drug systems may be verified by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Raman spectroscopy (RS) and Fourier transform infrared spectroscopy (FT-IR). Stability of co-amorphous drug systems is influenced by their glass transition temperature (Tg) and intermolecular interactions. The theoretical Tg values and the interaction parameter x are calculated by Gordon-Taylor equation and the Flory-Huggins equation, respectively. Thus, co-amorphous drug systems are analyzed theoretically at molecular level. Co-amorphous drug systems provide a new sight for the co-administration of medicines.
