Long-Term Outcomes of Homografts in the Aortic Valve and Root Position: A 20-Year Experience.
10.5090/kjtcs.2016.49.4.258
- Author:
Joo Yeon KIM
1
;
Joon Bum KIM
;
Sung Ho JUNG
;
Suk Jung CHOO
;
Cheol Hyun CHUNG
;
Jae Won LEE
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Korea. ctsjungsh@hanmail.net
- Publication Type:Original Article
- Keywords:
Aortic root;
Aortic valve;
Homograft;
Allograft
- MeSH:
Allografts*;
Aortic Valve*;
Aortitis;
Follow-Up Studies;
Freedom;
Heart;
Heart Transplantation;
Hemodynamics;
Humans;
Mortality;
Reoperation;
Retrospective Studies;
Survival Rate;
Thromboembolism;
Tissue Donors;
Transplant Recipients
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2016;49(4):258-263
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The advantages of using a homograft in valve replacement surgery are the excellent hemodynamic profile, low risk of thromboembolism, and low risk of prosthetic valve infection. The aim of this study was to evaluate the long-term outcomes of homograft implantation in the aortic valve position. METHODS: This is a retrospective study of 33 patients (>20 years old) who underwent aortic valve replacement or root replacement with homografts between April 1995 and May 2015. Valves were collected within 24 hours from explanted hearts of heart transplant recipients (<60 years) and organ donors who were not suitable for heart transplantation. The median follow-up duration was 35.6 months (range, 0 to 168 months). RESULTS: Aortic homografts were used in all patients. The 30-day mortality rate was 9.1%. The 1- and 5-year survival rates were 80.0%±7.3% and 60.8%±10.1%, respectively. The 1-, 5-, and 10-year freedom from reoperation rates were 92.3%±5.2%, 68.9%±10.2%, and 50.3%±13.6%, respectively. The 1-, 5-, and 10-year freedom from significant aortic dysfunction rates were 91.7%±8.0%, 41.7%±14.2%, and 25.0%±12.5%, respectively. CONCLUSION: Homografts had the advantages of a good hemodynamic profile and low risk of thromboembolic events, and with good outcomes in cases of aortitis.
