Recent advances in gene change of pancreatic cancer.
- Author:
Yu-yue WANG
1
;
Quan-cai CUI
Author Information
1. Department of Pathology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. wangyuyue2002@yahoo.com
- Publication Type:Journal Article
- MeSH:
Epidermal Growth Factor;
genetics;
Fibroblast Growth Factors;
genetics;
Genes, Tumor Suppressor;
Genes, myc;
genetics;
Genes, p16;
Genes, p53;
genetics;
Genes, ras;
genetics;
Growth Substances;
genetics;
metabolism;
Humans;
Oncogenes;
genetics;
Pancreatic Neoplasms;
genetics
- From:
Acta Academiae Medicinae Sinicae
2004;26(1):79-82
- CountryChina
- Language:Chinese
-
Abstract:
A large number of data derived from molecular analyses support the hypothesis that human cancer is a genetic disease and a distinct subset of genes have been found to be genetically changed in most tumors. Molecular alterations in pancreatic cancer include: (1) oncogenes such as K-ras, c-myc, c-fos, and c-erbB-2; (2) tumor suppressor genes such as p53, p16, DPC4/SMAD4, and DCC; and (3) growth factors such as EGF, FGF, HGF, PDGF, VEGF, TGF-beta. Genetic alterations of K-ras and p53 are common in human pancreatic cancer, but the occurrence of pancreatic cancer is a multi-step phenomenon in which the accumulation of genetic changes is extremely important.
