One case of correlation between the human herpesvirus 7 DNA load and the hemo hagocytic syndrome
10.3760/cma.j.issn.1003-9279.2011.02.014
- VernacularTitle:一例噬血细胞综合征与人疱疹病毒7型感染相关性的报告
- Author:
Peng CAI
1
;
Chun-Rong TONG
;
Jun-Fang YANG
;
Ying LIU
;
Guo-Lin XU
;
Gian-Feng ZHANG
;
Cheng-Liang ZHEN
;
Gun-Fang LI
;
Zhi-Ping TENG
Author Information
1. 北京市道培医院
- Keywords:
Histriocytosis,Non-langerhans cell;
Herpesvirus 7,human;
Ferritin
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(2):123-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the relationship between human herpesvirus 7 (HHV-7) viral Load and the etiopathogenisis of hemophagocytic syndrome, in order to provide evidence for the clinical diagnosis of hemophagocytic syndrome and anti-virus therapy. Methods Peripheral blood of patient with hemophagocytic syndrome during different treatment periods, extracted DNA, Syntheticed the primers of HHV-7,gene sequence of PCR amplified fragments detected, determined HHV-7 viral Load by Real - time fluorescent quantitative PCR and the ferritin concentration in peripheral blood detected by chemiluminescence. Result The sequence result indicated that PCR amplified fragment was a part of HHV-7 gene, the ferritin concentration viried with the load of HHV-7. Conclusion The occurrence of hemophagocytic syndrome is connetted with the load of HHV-7.
