Optimize excipients for Yinsang hypoglycemic granules by using multiple indexes.
10.19540/j.cnki.cjcmm.20161222.058
- Author:
Jun-Chao DU
1
;
Jian-Ming CHENG
1
;
Rui LIU
1
;
Xin-Zhi WANG
1
;
Qian ZHANG
1
;
Wen-Ying ZHANG
1
;
Hao WU
1
Author Information
1. Jiangsu Key Laboratory of Research and Development in Marine Bio-resoure Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing 210023, China.
- Publication Type:Journal Article
- Keywords:
Yinsang granules;
excipients;
hygroscopicity;
liquefaction
- From:
China Journal of Chinese Materia Medica
2017;42(2):285-289
- CountryChina
- Language:Chinese
-
Abstract:
Optimal excipients were screened by studying the effect of different excipients on the hygroscopicity of the extract, testing polysaccharide in the preparation and blood glucose value. Single factor tests were performed with hygroscopicity, formability and fluidity as the indexes, and the moisture content, granule yield and angle of repose were combined with physical characters of the materials to screen the proportioning and dosage of excipients. Then the critical relative humidity of preferred Yinsang granules were measured. The optimum excipients for Yinsang hypoglycemic granules were mulberry leaf paste-microcrystalline cellulose-mactra veneriformis crude polysaccharides (10∶9∶1.67). The obtained granules had good formability and fluidity, which were not easy to absorb moisture for liquefaction, with a critical relative humidity of 73%. This formation process was reasonable and feasible, suitable for industrial production, which can significantly improve hygroscopicity and liquefaction properties of extracts, improve stability of Yinsang granules, and provide reference for screening of excipients for other preparations.
